Cancer – Press Review  – Revue de Presse

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Press Review (January 26, 2013) – Revue de presse (26 janvier 2013)


Promising Prognostic Marker for Aggressive Breast Cancer
A team of researchers led by Goutham Narla, MD, PhD, at Case Western
Reserve University School of Medicine and University Hospitals Case
Medical Center, and collaborators at the Mount Sinai School of
Medicine and Erasmus Medical Center, have discovered a gene variant
that drives the spread of breast cancer. Published in Science
Translational Medicine, the study lays the early foundation for
predicting which breast cancer patients may develop more aggressive
disease and for designing more effective treatments.
In Science Daily
http://www.sciencedaily.com/releases/2013/01/130123195106.htm

Cancer expert remains to be convinced by breast screening review
Harms from breast cancer screening outweigh benefits if death caused
by treatment is included.
In EurekAlert (press release)
http://www.eurekalert.org/pub_releases/2013-01/bmj-cer012413.php

SNPs Associated With Breast Cancer Risk Alter Binding Affinity for
Pioneer Factor FOXA1
Dartmouth scientists showed that more than half of all the SNPs
associated with breast cancer risk are located in distant regions and
bound by FOXA1, a protein required for estrogen receptor-$B&A(B (ER)
function according to a paper published in the journal Nature Genetics
in November.
In Science Daily (press release)
http://www.sciencedaily.com/releases/2013/01/130123165044.htm

Personal Epigenetic 'Signatures' Found Consistent in Prostate Cancer
Patients' Metastases
In a genome-wide analysis of 13 metastatic prostate cancers,
scientists at the Johns Hopkins Kimmel Cancer Center found consistent
epigenetic "signatures" across all metastatic tumors in each patient.
The discovery of the stable, epigenetic "marks" that sit on the
nuclear DNA of cancer cells and alter gene expression, defies a
prevailing belief that the marks vary so much within each individual's
widespread cancers that they have little or no value as targets for
therapy or as biomarkers for treatment response and predicting disease
severity.
In Science Daily
http://www.sciencedaily.com/releases/2013/01/130123144041.htm

Researchers prevent cancer spread by blocking tissue scarring
Researchers at BRIC, University of Copenhagen have shown that the
enzyme Lysyl Oxidase (LOX) can create a "scarred" microenvironment
that enhances cancer spreading.
In Medical Xpress
http://medicalxpress.com/news/2013-01-cancer-blocking-tissue-scarring.html

Planning for Bacteria in Cancer Patients May Help Hospitals Fight
Infections
What cancerous conditions lead to what kinds of bacterial infections?
If doctors knew, they could predict which patients would likely
benefit from pre-treatment with certain kinds of antibiotics. A
University of Colorado Cancer Center study published in this month's
issue of the International Journal of Infectious Diseases shows the
answer: E. coli and Klebsiella pneumoniae are especially prevalent in
patients with lung and GI cancers, more so for Klebsiella if these
patients have been treated previously with aminopenicillins.
In Science Daily
http://www.sciencedaily.com/releases/2013/01/130123165105.htm

Research: Lupus drugs carry no significant cancer risk for patients
People who take immunosuppressive drugs to treat lupus do not
necessarily increase their cancer risk according to new research led
by scientists at the Research Institute of the McGill University
Health Centre (RI-MUHC). This landmark study, which was published in
Annals of the Rheumatic Diseases this month, addresses long-standing
fears of a link between lupus medication and cancer.
In EurekAlert (press release)
http://www.eurekalert.org/pub_releases/2013-01/muhc-rld012413.php

Can Metastasis of Triple-Negative Breast Cancer Be Thwarted?
Researchers have demonstrated how a particularly aggressive type of
breast cancer, triple-negative disease, spreads to other parts of the
body. The results may lead to new therapies that could treat
metastatic breast cancer. The findings are published in Cancer Cell.
By Anna Azvolinsky. In Cancer Network
http://www.cancernetwork.com/triple-negative-breast-cancer/content/article/10165/2124900


Informing women on breast cancer overdiagnosis
In a study exploring women's responses to being told about
overdiagnosis in breast cancer screening, most women felt the
information was important and could enable them to make choices.
In Medical Xpress
http://medicalxpress.com/news/2013-01-women-breast-cancer-overdiagnosis.html





Risque accru de cancer du poumon chez les fumeuses
Le risque de mourir d'un cancer du poumon a tr$(D??(Bs fortement augment$(D??(B
ces derni$(D??(Bres d$(D??(Bcennies chez les femmes qui fument, selon une $(D??(Btude
ayant port$(D??(B sur plus de deux millions d'Am$(D??(Bricains, rendue publique
mercredi.
Dans France24
http://www.france24.com/fr/20130124-risque-accru-cancer-poumon-fumeuses


Pourquoi les gros animaux sont-ils moins sujets au cancer que nous ?
Plus un animal est gros, plus il poss$(D??(Bde de cellules. Logiquement, on
pourrait penser que plus il y a de cellules dans un organisme, plus il
y a de risques de contracter un cancer. Pourtant, on constate le
ph$(D??(Bnom$(D??(Bne inverse. Cette contradiction, nomm$(D??(Be paradoxe de Peto, vient
d$B!G$(D??(Btre expliqu$(D??(Be par un mod$(D??(Ble math$(D??(Bmatique. Une justification qui ne
fait pas l$B!G(Bunanimit$(D??(B.
Par Janlou Chaput. Dans Futura-Sciences
http://www.futura-sciences.com/fr/news/t/biologie-3/d/pourquoi-les-gros-animaux-sont-ils-moins-sujets-au-cancer-que-nous_44182/

Cancer pancr$(D??(Batique stade IV : une association accro$(D??(Bt la survie
Selon les r$(D??(Bsultats d$B!G(Bune $(D??(Btude multicentrique de phase III,
l$B!G(Bassociation d$B!G(BAbraxane (nab paclitaxel) et de gemcitabine majore la
survie des patients atteints d$B!G(Bune forme avanc$(D??(Be de cancer
pancr$(D??(Batique.
Dans Le Quotidien du M$(D??(Bdecin
http://www.lequotidiendumedecin.fr/specialites/cancerologie/cancer-pancreatique-stade-iv-une-association-accroit-la-survie

Cancer: Une mortalit$(D??(B en baisse de 20% en 20 ans
C$B!G(Best le rapport annuel encourageant de l$B!G(BAmerican Cancer Society, qui
porte certes sur les Etats-Unis mais nous donne une tendance non
n$(D??(Bgligeable. Car dans ce seul pays, ce sont en 20 ann$(D??(Bes, 1,2 millions
de d$(D??(Bc$(D??(Bs par cancer qui ont $(D??(Bt$(D??(B pr$(D??(Bvenus soit plus de 150.000 pour la
seule ann$(D??(Be 2009. Les 4 cancers « les plus lourds » sont en
r$(D??(Bgression, mais certains cancers poursuivent leur progression, comme
le m$(D??(Blanome, le cancer de la thyro$(D??(Bde et du pancr$(D??(Bas. Des indications
pr$(D??(Bcieuses pour l$B!G(Bensemble des pays.
Dans Sant$(D??(B Log
http://www.santelog.com/news/cancerologie/cancer-une-mortalite-en-baisse-de-20-en-20-ans_9751_lirelasuite.htm

Calvitie pr$(D??(Bcoce: Un indicateur de risque de cancer de la prostate?
La science nous livre parfois de curieuses associations mais elles
trouvent toujours leur explication. Ici c$B!G(Best la calvitie pr$(D??(Bcoce,
c$B!G(Best-$(D??(B-dire vers 40 ans qui est associ$(D??(Be $(D??(B un risque accru de cancer
de la prostate. Cette $(D??(Btude australienne, pr$(D??(Bsent$(D??(Be dans Cancer
Epidemiology Biomarkers and Prevention qui, pr$(D??(Bcisons-le n$B!G(Ba pas
$(D??(Bvalu$(D??(B les taux de mortalit$(D??(B, ne doit pas d$(D??(Bsesp$(D??(Brer les hommes jeunes
atteint d$B!G(Balop$(D??(Bcie androg$(D??(Bn$(D??(Btique, en particulier, rappellent les
auteurs, parce que de nombreux cas de cancer de la prostate ne sont
pas agressifs.
Dans Sant$(D??(B Log
http://www.santelog.com/news/cancerologie/calvitie-precoce-un-indicateur-de-risque-de-cancer-de-la-prostate-_9791.htm








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